新生儿缺氧缺血性脑病患儿血清长链非编码RNA小核仁RNA宿主基因15、HOX转录物反义RNA表达及预后评估价值

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新生儿缺氧缺血性脑病患儿血清长链非编码RNA小核仁RNA宿主基因15、HOX转录物反义RNA表达及预后评估价值
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基金项目:河北省医学科学研究课题计划项目（20241842）；石家庄市科学技术研究与发展计划项目（201201153）

Serum expression of LncRNA small nuclear kernel RNA host gene 15 and LncRNA Hox transcript antisense RNA in neonates with hypoxie-ischemic encephalopathy and their correlation with prognosis

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目的探讨新生儿缺氧缺血性脑病（HIE）患儿血清长链非编码RNA 小核仁RNA宿主基因15（LncRNA SNHG15）及LncRNA HOX转录物反义RNA（HOTAIR）水平及预后评估价值。方法选取2021年1月—2023年2月我院收治的89例HIE患儿为HIE组，根据患儿病情严重程度分为轻度亚组(n=36)、中度亚组(n=31)、重度亚组(n=22)；根据预后分为预后良好亚组（n=65）和预后不良亚组（n=24）。以同期接受手术治疗的50例腹股沟斜疝或脐尿管瘘新生儿为对照组。采用实时荧光定量PCR检测血清LncRNA SNHG15及LncRNA HOTAIR的表达水平。采用Logistic回归模型分析筛选HIE患儿预后影响因素。利用ROC研究血清LncRNA SNHG15、LncRNA HOTAIR的预后评估价值。结果 HIE组血清LncRNA SNHG15、LncRNA HOTAIR水平高于对照组，差异有统计学意义（t=19.654，35.508，P＜0.001）。HIE患儿病情程度越重，血清LncRNA SNHG15、LncRNA HOTAIR水平越高（均P＜0.05）。预后不良亚组血清LncRNA SNHG15、LncRNA HOTAIR高于预后良好亚组，差异有统计学意义（均P<0.05）。血清LncRNA SNHG15及LncRNA HOTAIR高是影响新生儿HIE不良预后的危险因素（P<0.05）。血清LncRNA SNHG15、LncRNA HOTAIR联合对新生儿HIE不良预后评估的曲线下面积为0.884（95%CI：0.853～0.947），明显大于血清LncRNA SNHG15、LncRNA HOTAIR单项0.801（95%CI：0.790～0.848）、0.822（95%CI：0.773～0.831）（Z=4.612，4.883，P<0.001）。结论新生儿HIE患儿血清LncRNA SNHG15、LncRNA HOTAIR水平升高与病情严重程度有关，两者联合检测对新生儿HIE的预后具有较高的评估价值

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Objective To investigate the serum levels of long non coding RNA (LncRNA) small nuclear kernel RNA host gene 15 (SNHG15), LncRNA Hox transcript antisense RNA (HOTAIR) in neonates with hypoxic-ischemic encephalopathy (HIE) and their prognostic value.Methods 89 children with HIE admitted to our hospital from January 2021 to February 2023 were selected as the HIE group. According to the severity of HIE in children, they were divided into mild subgroup (n=36), moderate subgroup (n=31), and severe subgroup (n=22). According to the short-term prognosis of HIE patients at discharge, they were divided into a good prognosis subgroup (n=65) and a poor prognosis subgroup (n=24). 50 newborns with inguinal hernia or umbilical fistula who underwent surgery during the same period were selected as the control group. QPCR were used to detect the expression levels of serum LncRNA SNHG15 and LncRNA HOTAIR. Logistic regression model analysis was conducted on the prognostic factors for HIE. The prognostic value of serum LncRNA SNHG15 and LncRNA HOTAIR in HIE was analyzed by the ROC curve. Results The serum levels of LncRNA SNHG15 and LncRNA HOTAIR in HIE group were significantly higher than those in control group (t=19.654, 35.508, P<0.001). The levels of serum LncRNA SNHG15 and LncRNA HOTAIR in children with mild, moderate, and severe HIE were significantly increased in sequence (P<0.05). The serum LncRNA SNHG15 and LncRNA HOTAIR levels in the poor prognosis subgroup were higher than those in the good prognosis subgroup (P<0.05). High levels of serum LncRNA SNHG15 and LncRNA HOTAIR were risk factors for poor prognosis in HIE. The area under the curve (95% CI) of the combination of serum LncRNA SNHG15 and LncRNA HOTAIR for poor prognosis evaluation of HIE was 0.884 (0.853-0.947), significantly larger than that of serum LncRNA SNHG15 and LncRNA HOTAIR alone at 0.801 (0.790-0.848) and 0.822 (0.773-0.831) (Z=4.612, 4.883, P<0.001）. Conclusion The elevated levels of serum LncRNA SNHG15 and LncRNA HOTAIR in children with HIE are related to the severity of the disease. The combination of the two can effectively evaluate the prognosis of HIE patients

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在线发布日期: 2026-06-18

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