Objective To determine whether serum uric acid and sleep disorders are independent risk factors for obesity in infertile women. Methods Data were obtained from the continuous National Health and Nutrition Examination Survey (NHANES) cycles from 2013-2018. We used multivariate logistic regression models and subgroup analysis, trying to uncover the association in serum uric acid, sleep disorders and obesity in infertility. Results A total of 255 infertile females of reproductive age were recruited for the study. Weighted multivariate logistic regression analysis revealed higher serum uric acid (OR=2.82; 95% CI: 1.89~4.25) and sleep disorders (OR=3.07; 95% CI:1.39~6.76) were associated with obesity after adjusting for the covariates. We further found that sleep disorders and serum uric acid were independent risk factors for obesity in women with infertility, particularly those under 40. A nonlinear trend between the serum uric acid and obesity in infertile women was shown by smooth curve fitting (nonlinear P<0.001). Conclusion Serum uric acid levels and sleep disorders are independent risk factors for obesity in infertile women, especially in patients less than or equal to 40 years old