《超重/肥胖多囊卵巢综合征患者体重管理内分泌专家共识(2025版)》解读
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四川省科技厅重点研发项目(2024YFFK0076)


Interpretation of the Endocrinology expert consensus on weight management in overweight/obese patients with polycystic ovary syndrome(2025 edition)
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    摘要:

    目前,超过半数的多囊卵巢综合征(PCOS)患者合并超重/肥胖,超重/肥胖不仅显著增加PCOS的发生风险,还可通过加重胰岛素抵抗和高雄激素状态,进一步恶化代谢异常、生殖功能障碍及心理健康问题,并提高2型糖尿病、心血管疾病及子宫内膜病变等远期并发症风险。有效的体重管理是治疗关键。然而,既往针对该人群的体重管理策略在国内外缺乏统一的专家共识,临床实践中存在评估标准不一、干预路径不清及缺乏个体化等问题。2025年发布的《超重/肥胖多囊卵巢综合征患者体重管理内分泌专家共识》就超重/肥胖与PCOS的交互影响、超重/肥胖PCOS患者的临床特征、评估诊断、个体化治疗及管理目标进行了归纳及更新,为此类患者的诊断和体重管理提供了建议。本文通过对该共识进行详细解读,旨在提升超重/肥胖PCOS的规范化诊疗水平

    Abstract:

    Currently, more than half of patients with polycystic ovary syndrome (PCOS) are overweight or obese. Overweight and obesity not only significantly increase the risk of developing PCOS, but also exacerbate insulin resistance and hyperandrogenism, thereby worsening metabolic abnormalities, reproductive dysfunction, and psychological health problems, and increasing the long-term risk of complications such as type 2 diabetes mellitus, cardiovascular disease, and endometrial disorders. Effective weight management is therefore a cornerstone of treatment for this population. However, until recently, there has been a lack of systematic and unified expert consensus on weight management strategies for overweight/obese patients with PCOS, resulting in heterogeneity in clinical assessment, unclear intervention pathways, and insufficient individualization in practice. In 2025, the Endocrine Expert Consensus on Weight Management in Overweight/Obese Patients with Polycystic Ovary Syndrome was released, providing updated and comprehensive recommendations on the interaction between overweight/obesity and PCOS, the clinical characteristics of overweight/obese PCOS across the life course, assessment and diagnostic approaches, individualized treatment strategies, and short- and long-term management goals. This article provides a detailed interpretation of the consensus, aiming to promote standardized clinical management and improve overall outcomes in overweight/obese patients with PCOS

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  • 在线发布日期: 2026-05-19
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