Abstract:Objective To investigate the impact of hypertension (HT) on left ventricle (LV) motion function in coronary artery diseases (CAD) patients using computer tomography-feature tracking (CT-FT) technology. Methods 83 CAD patients were retrospectively enrolled from January 2024 to February 2025, and divided into two groups with [CAD (HT+), n=43] and without HT [CAD (HT-), n=40]. LV morphologic and function indices, and myocardial strain parameters were compared between the two groups. Strain analysis encompassed myocardial global longitudinal strain (Myo GLS), circumferential strain (Myo GCS), radial strain (Myo GRS) and endocardial global longitudinal strain (Endo GLS), circumferential strain (Endo GCS). The determinants of LV myocardial strain were subsequently identified by univariate correlation analysis and multivariable linear regression analysis. Results Compared with the CAD (HT-) group, patients in the CAD (HT+) group were older, showed a higher BMI and a higher proportion of coronary artery diseases Reporting and Data System (CAD-RADS) scores ≥3 (P<0.05). No significant difference of LV morphologic and function indices was observed between the two groups. As for LV myocardial strain metrics, the patients in CAD (HT+) group demonstrated lower values in Myo GLS -19.9-21.3,-18.1)% vs.-21.0 ± 2.7%, P=0.010] and Endo GLS (-23.1±3.2% vs.-25.0±4.0%, P=0.023)than CAD (HT-) group. In the multivariate linear regression analysis, HT and CAD-RADS scores ≥ 3 were both independently associated with the decreased of Myo GLS (HT: β=-0.271,P=0.007; CAD-RADS≥3: β=-0.284,P=0.004) and Endo GLS (HT: β=-0.229,P=0.031; CAD-RADS≥3: β=-0.256, P=0.016). Conclusion HT can aggravate the LV subclinical dysfunction in CAD patients and CT-FT technology allows the sensitive assessment