基于CT特征追踪技术探究高血压对冠状动脉疾病患者左心室心肌应力的影响
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国家自然科学基金青年科学基金项目(82202094);四川省科技厅自然科学基金青年基金项目(2023NSFSC1635)


Impact of hypertension on left ventricular myocardial strain in patients with coronary artery diseases using CT feature tracking technology
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    摘要:

    目的 通过CT特征追踪(CT-FT)技术探究高血压对冠状动脉疾病(CAD)患者左心室运动功能的影响。方法 回顾性纳入2024年1月—2025年2月四川省肿瘤医院收治的83例CAD患者,并根据有无高血压分为合并高血压组 [CAD(HT+)组,n=43]和无高血压组 [CAD(HT-),n=40]。对比两组患者左心室形态、功能及心肌应力参数,其中心肌应力参数包括心肌整体纵向应变 (Myo GLS)、周向应变(Myo GCS)、径向应变(Myo GRS)及心内膜下纵向应变(Endo GLS)、周向应变(Endo GCS)。采用单因素相关性分析及多因素线性回归分析探究影响左心室心肌应力的因素。结果 与 CAD(HT-)组患者相比,CAD(HT+)组患者平均年龄更高,BMI更大,冠状动脉疾病报告和数据系统(CAD-RADS)分级≥3级者占比更高(P<0.05)。两组患者间左心室形态、功能参数均未见明显差异(P>0.05)。针对左心室心肌应力,CAD(HT+)组患者的Myo GLS、Endo GLS均低于 CAD(HT-)组(均P<0.05)。多因素线性回归分析进一步显示,所有患者中合并高血压和CAD-RADS分级≥3与 Myo GLS、Endo GLS的降低独立相关(均P<0.05)。结论 高血压可加重CAD患者的左心室亚临床收缩功能障碍,CT-FT技术能够对此进行敏感的影像学评估

    Abstract:

    Objective To investigate the impact of hypertension (HT) on left ventricle (LV) motion function in coronary artery diseases (CAD) patients using computer tomography-feature tracking (CT-FT) technology. Methods 83 CAD patients were retrospectively enrolled from January 2024 to February 2025, and divided into two groups with [CAD (HT+), n=43] and without HT [CAD (HT-), n=40]. LV morphologic and function indices, and myocardial strain parameters were compared between the two groups. Strain analysis encompassed myocardial global longitudinal strain (Myo GLS), circumferential strain (Myo GCS), radial strain (Myo GRS) and endocardial global longitudinal strain (Endo GLS), circumferential strain (Endo GCS). The determinants of LV myocardial strain were subsequently identified by univariate correlation analysis and multivariable linear regression analysis. Results Compared with the CAD (HT-) group, patients in the CAD (HT+) group were older, showed a higher BMI and a higher proportion of coronary artery diseases Reporting and Data System (CAD-RADS) scores ≥3 (P<0.05). No significant difference of LV morphologic and function indices was observed between the two groups. As for LV myocardial strain metrics, the patients in CAD (HT+) group demonstrated lower values in Myo GLS -19.9-21.3,-18.1)% vs.-21.0 ± 2.7%, P=0.010] and Endo GLS (-23.1±3.2% vs.-25.0±4.0%, P=0.023)than CAD (HT-) group. In the multivariate linear regression analysis, HT and CAD-RADS scores ≥ 3 were both independently associated with the decreased of Myo GLS (HT: β=-0.271,P=0.007; CAD-RADS≥3: β=-0.284,P=0.004) and Endo GLS (HT: β=-0.229,P=0.031; CAD-RADS≥3: β=-0.256, P=0.016). Conclusion HT can aggravate the LV subclinical dysfunction in CAD patients and CT-FT technology allows the sensitive assessment

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  • 在线发布日期: 2026-04-17
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