颅内破裂动脉瘤患者弹簧圈栓塞术后神经系统并发症发生的相关因素及预测效能分析
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2022年度陕西省卫生健康委科研项目(2022D022)


Related factors of occurrence of neurological complications after coil embolization for ruptured intracranial aneurysms and analysis of predictive efficiency
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    目的 探究颅内破裂动脉瘤患者弹簧圈栓塞术后神经系统并发症发生的相关因素,并通过构建Logistic回归模型,分析相关因素的预测效能。方法 回顾性研究2021年2月—2024年2月在我院治疗的148例颅内破裂动脉瘤患者,均采用弹簧圈栓塞术治疗,随访3个月,统计术后神经系统并发症的发生情况,采用Logistic多因素回归分析影响术后神经系统并发症发生的危险因素,ROC曲线分析危险因素对术后神经系统并发症发生的预测效能。结果 随访期间,患者术后发生了神经系统并发症18例,术后未发生神经系统并发症有130例。分别纳入神经系统并发症组(n=18)和未发生神经系统并发症组(n=130)。与未发生神经系统并发症组相比,神经系统并发症组患者高血压、宽颈动脉瘤、动脉瘤有小阜占比更高(P<0.05);Logistic多因素回归分析显示,高血压、动脉瘤有小阜能够独立影响术后神经系统并发症的发生(P<0.05);ROC曲线结果显示,曲线下面积、95%CI分别为0.678、0.542~0.814,灵敏度、特异度分别为61.10%、73.10%。结论 高血压、动脉瘤有小阜是影响颅内破裂动脉瘤患者术后神经系统并发症发生的危险因素,对术后神经系统并发症发生具有一定的预测效能

    Abstract:

    Objective To explore the related factors of occurrence of neurological complications after coil embolization for ruptured intracranial aneurysms (IA), and analyze the predictive efficiency of related factors by constructing Logistic regression model. Methods Totally 148 patients with ruptured IA who received treatment in the hospital were retrospectively studied from February 2021 to February 2024, and were treated with coil embolization. After 3 months of follow-up, the occurrence of postoperative neurological complications was counted. Logistic multivariate regression analysis was adopted to analyze the risk factors affecting the occurrence of postoperative neurological complications. ROC curve was applied to analyze the predictive efficiency of risk factors on the occurrence of postoperative neurological complications.Results During follow-up, 18 cases had neurological complications after surgery, with an incidence of 12.16% (18/148), and 130 cases did not have neurological complications after surgery, which were included in the neurological complication group (n=18) and the non-neurological complication group (n=130) respectively. Compared with the non-neurological complication group, the proportions of hypertension, wide-necked aneurysms and aneurysm bleb in the neurological complications group were higher (P<0.05). Logistic multivariate regression analysis suggested that hypertension and aneurysm bleb could independently affect the occurrence of postoperative neurological complications (P<0.05). ROC curve indicated that the area under the curve, 95%CI, sensitivity and specificity were 0.678, 0.542-0.814, 61.10% and 73.10% respectively. Conclusion Hypertension and aneurysm bleb are risk factors for postoperative neurological complications in patients with ruptured IA, and have certain predictive efficacy on postoperative neurological complications

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  • 在线发布日期: 2026-04-17
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