Objective To investigate the effect of Bikangfu nasal tamponade therapy combined with the treatment of Tongqiao rhinitis granules on the inflammatory indicators and transforming growth factor-beta 1 of chronic rhinosinusitis in children. Methods One hundred and eight children with confirmed diagnosis of chronic sinusitis were selected for the study and were divided into 54 cases in the control group and 54 cases in the observation group using randomization method. The control group was given Tongqiao rhinitis granules, 2 g per sachet, 1/2 sachet each time, 3 times a day with boiled water. The observation group was treated with Bikangfu nasal tamponade therapy based on the control group, which was left in place for 20 min once a day. At the end of treatment, the levels of inflammatory factors (LTC4, IL-17) and inflammation-related proteins (ECP, AQP-3) in serum and nasal secretion fluid, changes in IgG, IE and T-lymphoid subgroups in serum and changes in the expression of key genes of the TGF-β1 pathway, Smad3, Smad7, αSMA, TGF β1, and TGFβ3 were compared between the 2 groups of children. 〖WTHZ〗Results The levels of LTC4, IL-17, ECP, IgE, and CD8+ in the serum and nasal secretions of the observation group were decreased, and the Lund-Kennedy endoscopy score was also reduced, all of which were lower than those in the control group (P＜0.05). The levels of AQP-3, IgG, CD3+, CD4+, CD4+/CD8+ in the serum and nasal secretion fluid of the children in the observation group were increased and were higher than those in the control group (P＜0.05). TGF-β1 pathway Smad3 gene expression was up-regulated and Smad7, α-SMA, TGFβ1, TGF-β3 gene expression was down-regulated after treatment(P＜0.05). There was no statistical significance in the occurrence of adverse reactions in children in the 2 groups (P＞0.05).Conclusion Bikangfu nasal tamponade therapy combined with Tongqiao rhinitis granules combination therapy can decrease LTC4, IL-17, ECP, IgE, and CD8+ levels, increase AQP-3, IgG, CD3+, CD4+, CD4+, and CD4+/CD8+ levels, and altere the structure of T-lymphoid subpopulations. The combination treatment alleviates the inflammatory response and reduces the expression level of TGF-β1 in the children