Objective To investigate the effect and predictive effect of the interval from cervical conectomy to pregnancy on premature rupture of membranes and neonatal outcome. Method The clinical data of 86 single primiparas with a history of cervical conectomy admitted to the 909th Hospital of Joint Logistics Support Force from June 2019 to June 2022 were retrospectively analyzed. The time interval from cervical conectomy to pregnancy was collected. The predictive effect of the time from conectomy and pregnancy on premature rupture of membranes to neonatal outcome was analyzed by the ROC curve. Univariate and Logistic regression models were used to analyze the influencing factors of premature rupture of membranes before term and neonatal outcome. Results The incidence of premature rupture of membranes before term was 38.37% (33/86). The area under the curve (AUC) of ROC curve analysis for predicting preterm premature rupture of membranes was 0.856, the maximum Youden index was 0.603, the optimal cut-off value was 10.5 (month), the sensitivity was 0.906, and the specificity was 0.697 95%CI was 0.772～0.940.The incidence of abortion history, gestational hypertension, hyperamniotic fluid, CKC, fetal position abnormality, cervical conectomy and gestation interval <10.5 months in the premature rupture group was higher than that in the non-premature rupture group (P<0.05), and the difference was statistically significant.Multivariate analysis showed that CKC(OR: 6.596, 95%CI: 1.287～33.795) and the interval from cervical conectomy to gestation <10.5 months (OR: 28.769, 95%CI: 5.761～143.671) were independent influencing factors for premature rupture of membranes (P<0.05). The incidence of adverse outcomes in neonates was 26.74% (23/86).The area under the curve (AUC) of ROC curve analysis for predicting neonatal adverse outcomes was 0.804, the maximum Youden index was 0.568, the cut-off value was 12.5 (months), and the sensitivity was 0.698. The specificity was 0.870 and 95%CI was 0.704～ 0.905. Univariate analysis showed that the incidence of abortion history, gestational hypertension, interval time from cervical conectomy to gestation <12.5 months, and premature rupture of membranes before term in the adverse neonatal outcome group was higher than that in the non-adverse neonatal outcome group (P<0.05), and the difference was statistically significant. Multivariate analysis found history of abortion (OR: 4.834, 95%CI: 1.094～21.367), gestational hypertension (OR: 16.068, 95%CI: 2.081～124.046), and interval from cervical conectomy to gestation <12.5 months (OR: 10.968, 95%CI: 2.254～53.377) were independent influencing factors of neonatal adverse outcomes (P<0.05). Conclusion For primiparous women, when the interval from cervical conectomy to gestation is less than 10.5 months and 12.5 months, respectively, it is an independent risk factor for premature rupture of membranes before term and adverse neonatal outcome, which has a predictive effect