In October 2025, the European Resuscitation Council (ERC) released its latest Guidelines for Cardiopulmonary Resuscitation and Cardiovascular Emergency Care. The updated guidelines optimize the entire chain of care—from prevention and early recognition to on-scene resuscitation and long-term management. They provide structured, evidence-based guidance not only for healthcare professionals, but also for lay rescuers and policymakers worldwide, while outlining several key directions for future research in resuscitation science. This article highlights the major updates in adult cardiopulmonary resuscitation (CPR), focusing on the development of resuscitation systems; basic and advanced life support (including compression quality, ventilation strategies, defibrillation protocols, management of CPR-induced consciousness, and the use of vasoactive or antiarrhythmic medications); resuscitation in special circumstances such as hyperthermia, poisoning, drowning, and obesity; and integrated post–cardiac arrest care involving respiratory, circulatory, and neurological support. This article provides an interpretation of core recommendations of the guideline, with the aim of offering insights for both clinical practice and research