Objective To explore the relationship between traditional tumor markers and vitamins A, C, E and selenium levels in patients with perimenopausal cervical cancerization.Methods 96 patients with perimenopausal cervical cancerization in the hospital were selected from October 2019 to October 2023 as the study group, and 96 subjects with perimenopausal health examination during the same period were included in the control group. The levels of traditional tumor markers (CEA, CA153, CA125) and vitamins A, C, E and selenium were compared between groups. The correlation between vitamins A, C, E and selenium levels and tumor markers was analyzed, and Logistic multivariate regression analysis was used to analyze the risk factors of perimenopausal cervical cancerization. Results The levels of CEA, CA153 and CA125 in the control group were lower than those in the study group (P<0.05) while serum levels of vitamins A, C, E and selenium were higher than those in the study group (P<0.05). Spearman correlation analysis showed that the levels of vitamins A, C and E and selenium were negatively correlated with cervical cancerization (P<0.05). Multivariate analysis suggested that reduced levels of vitamins A, C, E and selenium were risk factors for patients presenting with abnormal tumour marker levels (p<0.05), vitamin A>42.10 μg/100 mL, vitamin C>34.16 μmol, vitamin E>11.98 μg/100 mL, selenium 0.17 PPm, and the decreases of vitamin A, C, E and selenium levels were risk factors for cervical cancerization. Conclusion The levels of vitamins A, C, E and selenium are closely related to cervical cancerization. Vitamins A, C, E and selenium are protective factors for cervical cancerization. Improving the levels of vitamins A, C, E and selenium in perimenopausal women can play a positive role in preventing cervical cancerization