Objective To determine the relationship between MAPH score and TIMI blood flow after percutaneous coronary intervention in patients with N-STEMI. Methods A total of 172 patients with N-STEMI who received direct percutaneous coronary intervention for the first time in the emergency department of our hospital from January 2023 to December 2023 were collected. According to the TIMI blood flow score after PCI, patients were divided into a non reflow group (n=25) and a normal blood flow group (n=147). Compared the general information, laboratory indicators, MAPH scores, and high shear rate (HSR) and low shear rate (LSR) between the two groups. Results Compared with the two groups, the non reflow group had a higher MAPH score. Multivariate regression analysis showed that a MAPH score>1.5 (OR: 0.259; 95% CI: 0.123-0.546, P<0.01) was an independent predictor of TIMI blood flow in non ST segment elevation myocardial infarction patients after percutaneous coronary intervention. The MAPH score predictd low TIMI coronary blood flow in patients with non ST segment elevation myocardial infarction after percutaneous coronary intervention, with a sensitivity of 77.3% and specificity of 49.3% (AUC: 0.785, 95% CI: 0.698～0.871, P=0.000). Paired comparison of receiver operating characteristic (ROC) curves showd that the MAPH score was superior to other self parameters, as well as HSR and LSR in predicting higher thrombus burden.Conclusion MAPH score is a predictive indicator of no coronary artery reflow after PCI in patients with N-STEMI