Hepatic metastatic cancer refers to lesions formed by the metastasis of malignant tumors originating from other organs to the liver, which is significantly associated with patient survival outcomes. Intratumoral microbiota represent microbial communities colonizing within tumor tissues, which regulate disease progression through multiple pathways. Multiple studies have confirmed that intratumoral microbiota are involved in the initiation and progression of hepatic metastatic cancer. This article reviews the potential roles and regulatory mechanisms of intratumoral microbiota in hepatic metastatic cancer, aiming to provide references for its diagnosis and clinical translation