Objective To analyze the effect of compound anisodine combined with Yimaikang on diabetic retinopathy after cataract surgery. Methods 86 patients with diabetic retinopathy after cataract surgery admitted in our hospital from August 2021 to August 2023 were divided into two groups according to simple random method.43 cases in control group were treated with compound anisodine, 43 cases in study group were treated with Yimaikang on the basis of control group. Optical coherence tomography (OCT) was used to observe the retinopathy of the two groups 2 months after treatment and evaluate the efficacy. The hemodynamic index were compared between the two groups before and after treatment. The retinal thickness and average visual field defect of macular fovea were measured by OCT before and after treatment. The safety of the two groups was evaluated.Results The clinical efficacy of the study group was better than that of the control group 2 months after treatment, the bleeding spots, microangiomas and retinal hard exudates in the study group were significantly lower than those in the control group. After treatment, PSV and EDV in study group were higher than those in control group, RI was lower than those in control group (P＜0.05). The average visual field defect and retinal thickness of fovea in study group were significantly improved than those in control group (P＜0.05). There was no obvious adverse reaction in both groups, and there was no significant difference between groups (P＞0.05).Conclusion Compound anisodine combined with Yimaikang has a significant effect on diabetic retinopathy after cataract surgery, which can effectively improve the hemodynamics of patients, improve their visual field defect and pathological changes, and has a high safety