Objective To explore the changes of sex hormones in elderly patients with weakness syndrome. Methods A total of 310 patients admitted to our hospital and meeting the inclusion criteria were selected as the study objects. Fried frailty Scale score was measured from 08:00 to 09:00 on the second day of admission. At the same time, fasting blood was collected during this period to detect sex hormones (testosterone, estradiol, progesterone, prolactin, luteinizing hormone, follicle-stimulating hormone). There were 54 cases in group A, group B (132 cases), group C (92 cases) and group D (32 cases). According to the severity of frailty, they were divided into non-frailty group, pre-frailty group and frailty group. Explore the occurrence of senile frailty in different age stages and the changes of sex hormones in male and female body under different frailty levels.Results The proportion of fthenia in group A was 11.1%, group B 21.2%, group C 48.9% and group D 75.0%. There was statistical significance in testosterone non-asthenic group, pre-asthenic group and asthenic group (P< 0.01). There was statistical significance in estradiol non-asthenic group compared with asthenic group (P< 0.05). The comparison of luteinizing hormone in non-asthenic group, pre-asthenic group and asthenic group was statistically significant (P< 0.05). There was statistical significance in estradiol in non-asthenic group, pre-asthenic group and asthenic group (P< 0.01). The luteinizing hormone in non-asthenic group, pre-asthenic group and asthenic group were statistically significant (P< 0.05). There was statistical significance in non-FGH group, pre-fGH group and FGH group (P< 0.05).Conclusion The prevalence of senile asthenic syndrome increases with age. In the weak men, testosterone decreases and estradiol and luteinizing hormone increase. In weak women, Estradiol decreased, luteinizing hormone and follicle-stimulating hormone increase