育龄期女性血清AMH水平与甲状腺自身抗体的相关性分析
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新疆维吾尔自治区自然科学基金资助项目(2021D01C133, 2020D01C130);自治区卫生健康青年医学科技人才专项科研项目(WJWY-202204)


Correlation analysis between serum AMH levels and thyroid autoantibodies in women of childbearing age
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    摘要:

    目的 探讨育龄女性抗缪勒管激素(AMH)水平与甲状腺自身抗体及甲状腺功能指标的相关性。方法 选取2015—2021年在本院就诊 18~50 岁之间的育龄期女性2833例,平均(33.68±7.05) 岁。按年龄、甲状腺自身抗体水平比较各组AMH水平,并分析甲状腺功能指标与AMH水平的相关性。结果 该人群AMH水平为1.92(0.62,3.74) μg/L,甲状腺球蛋白抗体(TgAb)阳性率为 22.06%,抗甲状腺过氧化物酶抗体(TPOAb)阳性率为22.66%,桥本甲状腺炎(HT)的检出率为 32.12%。随着年龄的增长,AMH水平呈下降趋势,TSH、TPOAb及TgAb滴度呈上升趋势,差异有统计学意义(P<0.05)。与抗体阴性组比较,单纯TPOAb阳性组及抗体均阳性组年龄较大,AMH、FT3、FT4水平更低,TSH水平更高,差异均有统计学意义(P<0.05);与单纯TgAb阳性组比较,单纯TPOAb阳性组年龄较大,TSH水平更高,FT3、FT4水平更低,差异均有统计学意义(P<0.05);抗体均阳性组较单纯TgAb阳性组TSH水平更高、FT4水平更低,差异均有统计学意义(P<0.05)。控制年龄后,AMH与FT 4成极弱的正相关(r1=0.039、 P1=0.038),与TPOAb呈极弱的负相关(r1 =- 0.038、P1=0.045)。结论 甲状腺自身抗体与卵巢贮备功能相关,建议在备孕前向患者宣教并进行甲状腺功能筛查和AMH检测

    Abstract:

    Objective To explore the correlation of anti-Müllerian hormone (AMH) level with thyroid autoantibodies and the thyroid function indicators in women of childbearing age, so as to provide guidance on prenatal and postnatal care. 〖WTHZ〗Methods 2, 833 women of childbearing age from 18 to 50 (mean 33.68 ± 7.05) years who visited a top level hospital in Xinjiang from 2015 to 2021 were collected as the study subjects. AMH levels in each group were compared by age and thyroid autoantibody levels, and the correlation between the thyroid function indicators and AMH level was analyzed. Results In the study population, the AMH level was 1.92 (0.62,3.74) μg /L, the positive rate of TgAb was 22.06%, the positive rate of TPOAb was 22.66%,the detection rate of Hashimoto's thyroiditis (HT) was 32.12%. With increasing age, AMH tended to decrease, while TSH and TPOAb and TgAb titers tended to increase, with statistically significant differences (P<0.05). Compared with the antibody-negative group, the groups positive for TPOAb alone and for both TgAb and TPOAb had older age, lower AMH levels, and higher FSH, FT3, and FT4 levels, with statistically significant differences (P<0.05). Compared with the group positive for TgAb alone, the group positive for TPOAb alone had older age and higher FSH, FT3, and FT4 levels, and the group positive for both TgAb and TPOAb had higher FSH and FT4 levels, with statistically significant differences (P<0.05) .After controlling for age, AMH showed a very weak positive correlation with FT4 (r1=0.039, P1=0.038), and a very weak negative correlation with TPOAb (r1=-0.038, P1=0.045). Conclusion Thyroid autoantibodies are related to the ovarian reserve function . It is recommended to educate the patient and perform thyroid function screening and AMH testing before preparing for pregnancy

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  • 在线发布日期: 2025-05-23
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