Objective To investigate the ultrasonographic features of fetal limb-body wall syndrome (LBWC) and explore the value of prenatal ultrasound in the diagnosis of fetal LBWC syndrome during early pregnancy.Methods The ultrasonographic data and follow-up results of 38 cases of fetal LBWC diagnosed by prenatal ultrasound during early pregnancy (11-13+6 wk) were retrospectively analyzed, and their ultrasonographic characteristics were analyzed. Results Among the 38 fetuses with limb wall abnormalities, there were spinal dysplasia(38/38, 100.00%), varying degrees of thoracoschisis and gastroschisis (38/38, 100.00%), limb dysplasia in 13 cases (13/38, 34.21%), craniocerebral malformations in 5 cases Ultrasound diagnosis of fetal LBWC (6/38, 15.79%), thickening of the transparent layer of the neck in 12 cases (12/38, 31.58%), and umbilical cord abnormalities in 38 cases (38/38, 100.00%), single umbilical artery in 3 cases (3/38, 7.89%)，cyst of umbilical cord in 1case (1/38, 2.64%). Conclusion Prenatal ultrasound in early pregnancy can detect LBWC as early as possible, and correct prenatal evaluation provides important guidance value for pregnancy decision-making and early intervention