Objective To explore the efficacy of local injection of platelet-rich plasma (PRP) combined with platelet gel in the treatment of postoperative wound healing in orthopedics, and analyze the risk factors of postoperative wound infection, and construct a prediction model of postoperative wound infection to verify its predictive value. Methods A total of 60 patients who underwent orthopedic surgery in our hospital from September 2022 to September 2023 were selected as the observation group, and all of them were treated with local injection of PRP combined with platelet gel covering the wound after operation. In addition, 60 patients who underwent orthopedic surgery in the same period were selected as the control group, and treated with local injection of PRP after operation. The therapeutic effects of wound healing after operation in the observation group and the control group were compared. Patients in the observation group were divided into infected group (12 cases) and uninfected group (48 cases) according to whether the wound was infected after operation. Multivariate Logistic regression model was used to analyze the risk factors of wound infection after orthopedic operation. To construct a nomogram prediction model for the risk of wound infection after orthopedic surgery and evaluate its prediction efficiency. Results The total effective rate in the observation group was 93.33%(56/60), which was higher than that in the control group (80.00%, 48/60) (P<0.05). Among 60 patients, 12 cases had wound infection after operation, and the infection rate was 20.00%. Logistic regression analysis showed that open wound type, operation time ≥2 h, incision type Ⅱ ~ Ⅲ, combined use of antibacterial drugs for ≥7 d, hospitalization time ≥2 weeks, and diabetes mellitus were all risk factors for wound infection after orthopedic surgery (OR=5.223, 3.655, 3.114, 3.564, 3.469, 3.554, 95%CI=1.312~9.144, 1.225~6.084, 1.354~4.875, 1.301~5.828, 1.245~5.638, 1.245~5.882, 1.354~5.058, P＜0.001）. The area under ROC curve was 0.875 (95%CI: 0.826 ~ 0.963), the specificity was 85.78% and the sensitivity was 82.34%. Hosmer-Lemeshow goodness-of-fit test showed no significant difference (χ2=2.462,P=0.128). The nomogram prediction model has good discrimination and high calibration. Conclusion Local injection of PRP combined with platelet gel is effective in the treatment of wound healing after orthopedic surgery. Trauma type, operation time, incision type, combined use time of antibacterial drugs, hospital stay and diabetes mellitus are all risk factors of wound infection after orthopedic surgery. The prediction model can accurately predict the risk of wound infection after orthopedic surgery and provide basis for taking early intervention measure