Objective By observing the "14-item uremia pruritus scale", TCM syndrome score, serum calcium, phosphorus levels, creatinine and urea in patients with maintenance hemodialysis pruritus by "Shenhuang Zhiyang Lotion" combined with ultrapure dialysate dialysis Changes in clinical data before and after treatment were evaluated to evaluate its clinical efficacy. Methods The subjects of the study were patients who were diagnosed with chronic renal insufficiency (uremia stage) in the Department of Nephrology of Shanghai Traditional Chinese Medicine Hospital from March 2021 to September 2021, were receiving continuous hemodialysis treatment, and were accompanied by itchy skin. The duration of maintenance hemodialysis was more than 3 months, the condition was stable, and there were no related contraindications. A total of 60 patients with pruritus on hemodialysis were included in this study, and they were randomly divided into a control group and a treatment group, 30 cases in each group. The control group was given routine adjuvant therapy, including daily skin cleaning, drug control of blood sugar and blood pressure according to the patient's condition, and dialysis with ultrapure dialysate three times a week combined with external application of chlordiazepoxide. The treatment group received conventional adjuvant therapy combined with ultrapure dialysate dialysis three times a week and external application of "Shenhuang Zhiyang Lotion" for 8 weeks. Results Before treatment, the general information (gender, age), pruritus score, TCM syndrome score and laboratory indexes of the two groups were not statistically significant (P＞0.05), which were comparable. The pruritus scores of the two groups decreased after treatment, and the treatment group was lower than the control group, and the difference between the two groups was statistically significant (P＜0.05). 3. The TCM syndrome scores of the two groups were decreased after treatment, and the treatment group was lower than the control group, and the difference between the two groups was statistically significant (P＜0.05). During the clinical observation, there were no adverse reactions in the treatment group and the control group.Conclusion "Shenhuang Antipruritic Lotion" can significantly improve the TCM syndrome scores and pruritus scores of patients with pruritus on hemodialysis, and improve clinical symptoms. No obvious adverse reactions occurred during the external application of "Shenhuang Antipruritic Lotion"