Objective To observe the clinical effect of Yifeng acupoint injection combined with Kaibi decoction in treating adult chronic secretory otitis media. Methods The data of 150 cases of chronic secretory otitis media were analyzed prospectively. According to the principle of randomised control, the patients were divided into three groups, traditional Chinese medicine group, acupoint injection group and needle-medicine combination group, with 50 cases in each group. In the Chinese medicine group, the self-formulated traditional Chinese medicine Kaibi decoction was taken orally, in the acupoint injection group, Yifeng acupoint injection was used, and in the needle-medicine combination group, Yifeng acupoint injection was combined with the traditional Chinese medicine Kaibi decoction, and the clinical efficacy of the three groups was compared. Results The total effective rate of the needle-medicine combination group was 86%, which was significantly higher than that of the traditional Chinese medicine group (56%) and the acupoint injection group (62%), with statistically significant differences (P＜0.05). Pure tone hearing thresholds of the three groups were improved compared with the pre-treatment period, and the improvement of the needle-medicine combination group was significantly better than that of the traditional Chinese medicine group and the acupoint injection group (P＜0.05). The a-type tympanic ventricular acoustic conductance impedance map of the three groups increased after treatment compared with that before treatment, and the proportion of the needle-medicine combination group was higher than that of the traditional Chinese medicine group and the acupoint injection group (P＜0.05). Conclusion The efficacy of Yifeng acupoint injection therapy combined with Chinese medicine Kaibi decoction in treating chronic secretory otitis media in adults is better than that of Chinese medicine or acupoint injection alone, and it is safe, so the combination of needle-medicine can be used in the clinical treatment of chronic secretory otitis media in adults