Uric acid is the final product of purine metabolism. The level of serum uric acid is mainly determined by the balance between the production and excretion of uric acid. Uric acid excretion is mainly in the kidney, followed by the intestinal tract. Through the complex renal tubular epithelial transport system, it accelerates the reabsorption and secretion of uric acid. It has been found that a variety of uric acid transporters in the kidney participate in the reabsorption and secretion of uric acid. In epidemiology, it has also been found that there are significant gender differences in gout and hyperuricemia. A large number of studies also show that sex hormones are related to uric acid. It is speculated that sex hormones may regulate blood uric acid levels by affecting uric acid transporters. This article reviews the relevant research on sex hormones in uric acid transporters in recent years