Objective To explore the predictive value of color Doppler flow imaging (CDFI) in fetal growth restriction (FGR) during pregnancy. Methods A total of 102 pregnant women in late pregnancy undergoing regular pregnancy tests in the hospital were enrolled as the research objects from March 2020 to August 2022,including 31 cases with late-onset FGR in FGR group and 71 normal cases in control group. The fetal growth and development indexes, blood flow parameters of uterine artery, umbilical artery and middle cerebral artery, and pregnancy outcomes were compared between the two groups. The predictive value of blood flow parameters for FGR was analyzed.Results The FETAL head circumference, biparietal diameter, abdominal circumference and femur diameter in FGR group were lower than those in control group(P＜0.05). PI, RI and S/D of maternal uterine artery and fetal umbilical artery in FGR group were higher than those in control group, while PI and RI of fetal middle cerebral artery were lower than those in control group(P＜0.05). PI, RI and S/D of uterine artery, PI, RI and S/D of fetal umbilical artery, PI and RI of fetal middle cerebral artery were of certain predictive value for FGR, and the area under the curve (AUC) values of 0.677, 0.721, 0.722, 0.674, 0.695, 0.700, 0.702 and 0.672, respectively. AUC of combined detection was 0.852, greater than that of single index (P＜0.05). The incidence of emergency cesarean section, premature delivery, 1 min Apgar score <7 points and transfer to neonatal intensive care unit (NICU) in FGR group was higher than that in control group, while gestational age and neonatal birth weight were lower than those in control group(P＜0.05). Conclusion CDFI can be applied to predict late onset FGR during pregnancy. The combined detection with blood flow parameters of uterine artery, umbilical artery and middle cerebral artery has higher predictive efficiency