Objective To investigate the correlation of serum podoplanin (PDPN) and angiopoietin-like protein 4 (Angptl4) levels with the hypercoagulable state of membranous nephropathy(MN) and their diagnostic value. Methods 45 patients with MN, 19 patients with IgA nephropathy and 20 patients with other glomerular diseases diagnosed by renal biopsy in the Department of Nephrology of the First Affiliated Hospital of Bengbu Medical College from December 2021 to September 2022 were selected as the study subjects, and 30 healthy physical examiners were used as the control group. According to the formation of hypercoagulable state, the MN group was divided into hypercoagulable group (n=26) and non-hypercoagulable group (n=19). The serum levels of PDPN and Angptl4 were measured by applying enzyme-linked immunosorbent assay (ELISA),and the levels of PDPN and Angptl4 in each group were compared and analyzed. Results Serum PDPN levels were higher in the MN group than in the IgA nephropathy group, other pathological types and the control group. The serum PDPN level of MN group was statistically significant different from IgA nephropathy group and control group (P1<0.05, P3<0.01), but wasn't statistically significant different from other pathological type groups (P2>0.05). Serum Angptl4 levels in the MN group were lower than those in the IgA nephropathy group, the other pathological types and the control group. The serum Angptl4 level of MN group was statistically significant different from IgA nephropathy group and control group (P1<0.05, P3<0.01), but had no statistically significant differences with other pathological type groups (P2>0.05). In MN patients, serum PDPN level was positively correlated with 24h urinary protein and fibrinogen; serum Angptl4 level was positively correlated with albumin, prothrombin time and activated partial thrombin time, and negatively correlated with serum cholesterol (P＜0.05)PDPN, cholesterol, D-dimer and fibrinogen were higher in the hypercoagulable group than in the non-hypercoagulable group, while Angptl4, albumin and prothrombin time were lower than in the non-hypercoagulable group, with statistically significant differences (P＜0.05). Multifactorial regression analysis showed that serum PDPN was an important risk factor for MN hypercoagulable state (OR=1.007, 95%CI:1.000-1.013, P=0.036). The area under the curve of PDPN predicting the formation of hypercoagulable state in PMN patients was 0.705 (95%CI:0.550-0.860, P=0.020); the sensitivity and specificity were 80.8% and 57.9%, respectively. Conclusion High levels of serum PDPN are an important risk factor for the development of hypercoagulable state in MN. Whether it can be used as a marker for preventive anticoagulation remains to be further studied. However, the level of serum Angptl4 has no diagnostic significance