Objective To observe the clinical effect of the hospital preparation Qianyang Yuyin in improving the blood pressure, Traditional Chinese medical science premonitory score, and blood vessel function of grade 1 hypertension of yin deficiency and yang hyperactivity type. Methods There were 84 patients had grade 1 hypertension of yinxu yangkang were stochastic divided into two groups. The code was given with the help of R statistical software to generate the treated groups, covering 12 cases of shedding (There were 6 cases in experimental group and 6 cases in control group), 72 cases of completing the test (37 and 35 cases in the experimental group and the control group respectively), and the control group was lifestyle intervention, the experimental group was lifestyle plus Qianyang Yuyin granule as the experimental group. The effects of hypotension, TCM syndrome, carotid PWV, carotid IMT, liver and kidney function and blood lipid of the two groups were observed for 3 months. Independent sample t-test or Wilcoxon rank sum test and χ2 test were used to compare the efficacy and safety indexes of the experimental group and the control group, and paired samplet -test or Wilcoxon signed rank test were used to compare the efficacy and safety indexes before and after treatment. Results In the aspect of TCM syndrome improvement, compared with the control group, the total score of TCM syndrome in experimental group was lower, and the difference was statistically significant (P<0.05).In terms of TCM syndromes, the improvement of vertigo, headache and other syndromes after experimental group was statistically significant compared with the control group (P<0.05).Compared with the control group, the change range of systolic blood pressure difference of Qianyang Yuyin granule was significantly higher than that of the control group (P<0.05), and the diastolic blood pressure was not statistically significant (P>0.05). During the follow-up period, there was a significant difference between the two groups in systolic blood pressure at the 8th and 12th weeks (P<0.05). In terms of vascular function improvement, Pulse wave velocity-beginning of the systole before and after treatment (PWV-BS), Pulse Wave velocity-ending of the systole (PWV-ES) and IMT, there were no significant differences between the experimental group and the control group (P>0.05). In terms of safety, there were no significant changes in blood biochemistry and electrocardiogram before and after treatment in both groups. Conclusion Qianyang Yuyin granule has advantages in improving blood pressure and syndrome of TCM in grade 1 hypertension patients with Yinxu Yangkang, but has no distinct advantage in improving vascular function during the observation period