Objective To explore the value of SYNTAX score combined with levels of serum N-terminal pro-B-type natriuretic peptide (NT-pro BNP), creatine kinase isoenzyme (CK-MB) and cardiac troponin I (cTnI) on the evaluation of prognosis of acute myocardial infarction (AMI) undergoing coronary intervention. Methods 85 patients with AMI who underwent coronary intervention in the hospital were selected as the study subjects. All patients received coronary angiography before surgery. SYNTAX score was used to evaluate the coronary lesion degree, and serum levels of NT-pro BNP, CK-MB and cTnI were measured during hospitalization. At 6 months of follow-up after surgery, the patients were divided into good prognosis group and poor prognosis group according to whether there were main adverse cardiovascular and cerebrovascular events (MACCE) after surgery. The general clinical data, SYNTAX score and serum levels of NT-pro BNP, CK-MB and cTnI were compared between the two groups. Multivariate Logistic regression analysis was used to analyze the influencing factors of prognosis in patients with AMI undergoing coronary intervention, and the evaluated value of SYNTAX score combined with serum levels of NT-pro BNP, CK-MB and cTnI on the prognosis in AMI patients undergoing coronary intervention was analyzed by receiver operating characteristic curve. Results There were no statistical differences in gender, age, BMI, combined with hypertension and diabetes mellitus, stroke history, serum TC, TG, HDL-C, LDL-C, Scr, LVEF, SV, CO and LVEDD between the two groups (P＞0.05). There were statistically significant differences in the proportion of history of myocardial infarction, Killip grading, lesion count distribution, stent implantation count, interventionary treatment time and hospital stay between good prognosis group and poor prognosis group (P＜0.05). The SYNTAX score and levels of serum NT-pro BNP, CK-MB and cTnI in poor prognosis group were significantly higher than those in good prognosis group (P＜0.05). Multivariate Logistic regression analysis showed that the lesion count, stent implantation count, SYNTAX score, serum NT-pro BNP, CK-MB and cTnI levels were risk factors affecting the prognosis of AMI patients undergoing coronary intervention (P＜0.05). ROC curve revealed that the AUCs of SYNTAX score, NT-pro BNP, CK-MB and cTnI alone and in combination in predicting the prognosis of AMI patients undergoing coronary intervention were 0.747, 0.754, 0.752, 0.881 and 0.952 respectively, and the combination had high diagnostic value. Conclusion SYNTAX score combined with serum levels of NT-pro BNP, CK-MB and cTnI can effectively predict MACCE after AMI coronary intervention, and the combined prediction efficiency is significantly improved