Objective To investigate the clinical value of loop-mediated isothermal amplification (LAMP) in the patients with chronic obstructive pulmonary disease combined with community-acquired pneumonia. Methods A total of 343 patients with chronic obstructive pulmonary disease combined with community-acquired pneumonia admitted to the department of respiratory and critical care medicine of the Affiliated Hospital of Southwestern Medical University from August 1, 2020 to November 31, 2022 were retrospectively analyzed. The basic information of patients was collected. Further, the sputum samples were collected from patients for bacterial culture and LAMP simultaneously.Results The difference was especially notable between the positive rate of LAMP(49.85%) and the sputum culture (20.99% )(χ2=13.989, P＜0.001). The Kappa test showed that Escherichia coli （Eco） were the bacteria with the greatest consistency coefficient (Kappa 0.796) and the consistency of Acinetobacter baumannii (Ab),Pseudomonas aeruginosa (Pae), Klebsiella pneumoniae (Kpn),Staphylococcus aureus (Sau), Methicillin-resistant staphylococcus (MRS) and Stenotrophomonas maltophilia (Sm) (Kappa＞0.4 ) while Haemophilus influenzae (Hi) were inconsistent (Kappa=0.174 ). Conclusion The LAMP is able to identify pathogens quickly and accurately, which helps in the early identification of patients with COPD combined with CAP, and has a certain significance in guiding the diagnosis and treatment of patient