Objective To investigate the application of "Zhibian through Shuidao" acupuncture in patients with chronic prostatitis (CP), and the influence on small particles of lecithin and quality of sexual life. Methods 116 patients with CP admitted to the hospital from January 2022 to March 2023 were selected as the research subjects. They were divided into two groups by random number table method, with 58 cases in each group. Both groups were given common treatment. The control group was given conventional drug treatment, while the treatment group was treated with "Zhibian through Shuidao" acupuncture. The efficacy, traditional Chinese medicine syndrome scores, improvement of small particles of lecithin, and quality of sexual life were compared between the two groups. Results The treatment response rate in the treatment group (89.66%) was higher than that in the control group (74.14%) (P＜0.05). After treatment, the scores for pain symptoms, systemic symptoms, urination symptoms, and tongue and pulse in the two groups decreased, and the treatment group had lower scores than the control group (P＜0.05). After treatment, the scores for small particles of lecithin in both groups decreased, and the treatment group had lower scores than the control group (P＜0.05). After treatment, the Chinese Index of Premature Ejaculation-5 (CIPE-5) scores in both groups decreased, and the treatment group had lower scores than the control group (P＜0.05). Conclusion "Zhibian through Shuidao" acupuncture can improve the therapeutic effect on CP, reduce traditional Chinese medicine syndrome scores, improve small particles of lecithin, and improve the quality of sexual life