Objective To observe the efficacy of nifedipine controlled release tablets combined with labetalol in the treatment of patients with pregnancy-induced hypertension Methods 156 patients with pregnancy-induced hypertesion admitted to the hospital from January 2019 to January 2022 were selected and divided into control group (n=78, nifedipine controlled release tablets) and observation group (n=78, nifedipine controlled release tablets + labetalol) by simple randomization method, and both groups were treated for 30 days. The therapeutic efficacy, and blood pressure, hemorheology and hemodynamics changes and expression levels of serum factors before and after treatment were compared between the two groups. Maternal-infant outcomes were followed up in the two groups, and adverse reactions during treatment were statistically analyzed. Results The total effective rate in observation group was 93.59%, which was significantly higher than 83.33% in control group (P＜0.05). After treatment, the diastolic blood pressure and systolic blood pressure of the two groups were reduced compared with those before treatment (P＜0.05), and the diastolic blood pressure and systolic blood pressure were significantly lower in observation group compared to control group (P＜0.05), and the differences between the two groups were statistically significant (P＜0.05). The hemorheological indicators and hemodynamic indicators in both groups were decreased after treatment compared with those before treatment (P＜0.05), and the above indicators in observation group were significantly lower than those in control group (P＜0.05), and the differences of the above indicators between the two groups were statistically significant (P＜0.05). After treatment, the hs-CRP in the two groups was declined (P＜0.05) while the PGE2 and APN were risen compared to before treatment (P＜0.05), and hs-CRP in observation group was significantly lower (P＜0.05) while PGE2 and APN were significantly higher than those in control group (P＜0.05), and the differences between both groups were statistically significant (P＜0.05). The incidence rate of cesarean section in observation group was significantly lower than that in control group (P＜0.05).Conclusion The combination of nifedipine controlled release tablets and labetalol can effectively control the blood pressure, enhance the hemorheological and hemodynamic indicators, and improve the maternal-infant outcomes in patients with pregnancy-induced hypertension