Objective To investigate the correlation between Aortoseptal angle (Ao SA) and ascending aorta elasticity in patients with Sigmoid shaped interventricular septum (SSIVS) by echocardiography. Methods A total of 82 patients with SSIVS were selected as the research objects. These patients were divided into A group (n=42) and B group (n=40) according to the Ao SA. Another 40 healthy volunteers matched in age and sex were selected as the control group. Conventional echocardiographic data were measured by two-dimensional ultrasound. The Systolic diameter of AAO (ASD) and diastolic diameter of AAO (ADD) were measured by M-mode echocardiography. The peak velocity during systole (SAo), early contraction peak velocity during diastole (EAo), and late contraction peak velocities during diastole were measured by tissue Doppler imaging. Then the differences of the above data were compared among the groups, and the correlation between Ao SA and the elasticity of ascending aorta in patients with SSIVS was evaluated. Results Compared with the control group, the proportion of hypertension in SSIVS was significantly increased, and bIVS, mIVS, Vlvot, ASD, ADD were increased, SAo and EAo were decreased. Compared with group A, bIVS and ASD were increased, and SAo was decreased in group B(P＜0.05). Pearon correlation analysis showed that Ao SA was negatively correlated with ASD, ADD(r=-0.372,-0.325; P＜0.05), and positively correlated with SAo,EAo(r=0.410,0.329;P＜0.05).Conclusion Ao SA is related to the elasticity of ascending aorta in patients with SSIVS，When the Ao SA decreases, the ascending aorta elasticity is vulnerable to damage. Early targeted assessment of the ascending aorta elasticity in patients with relatively small Ao SA and timely intervention are helpful to delay the occurrence of complications