Objective To evaluate the current situation of renal anemia in maintenance hemodialysis patients in single-center and explore its related factors. Methods Patients undergoing maintenance hemodialysis in the Blood purification Center of the people's Hospital of Tibet Autonomous region from January 2019 to May 2022 were collected. The patients were selected according to the inclusion criteria and exclusion criteria, and the general data and clinical related indicators were analyzed retrospectively. Hemoglobin ＜110 g/L was divided into substandard group, and hemoglobin ≥110 g/L group was divided into standard group. Results A total of 193 patients with maintenance hemodialysis were enrolled, with an average of (53.46 ±14.28) years old, 121 males and 72 females, living at an altitude of 2200 to 4700 meters above sea level. There were 115 cases whose hemoglobin did not meet the standard, 78 cases reached the standard, the rate of hemoglobin reaching the standard was 40.4%, and the prevalence rate of anemia was 59.6%. The levels of hemoglobin, serum albumin, transferrin saturation and Kt/V in the patients with substandard hemoglobin were significantly lower than those in the control group, while the levels of ferritin and C-reactive protein in the substandard group were significantly higher than those in the control group. There was no significant difference in age, sex, etiology, dialysis age, serum calcium, phosphorus, parathyroid hormone, total cholesterol, triglyceride, serum creatinine and blood urea nitrogen between the substandard group and the standard group (P＞0.05) Multivariate Logistic regression analysis showed that low serum albumin and low Kt/V were independent risk factors for renal anemia in maintenance hemodialysis patients. Conclusion The anemia standard rate of maintenance hemodialysis patients in People's Hospital of Tibet Autonomous Region is low. Low serum albumin and low Kt/V are independent risk factors of anemia. Clinical attention should be paid to the above factors and positive measures should be taken to increase the anemia standard rate and improve the prognosis of patients