Objective To explore the clinicopathological features and prognosis of Henoch-Schonlein purpura nephritis in Yi children.Methods The clinical data of 383 cases of children with purpura nephritis diagnosed in our hospital were collected from January 2014 to December 2019, and 52 cases of children with perfect renal tissue biopsy were collected, and clinical and pathological data were retrospectively analyzed to summarize the age, gender, ethnic distribution, clinicopathological characteristics and prognosis of children with purpura nephritis in the Yi ethnic region of Liangshan.Results Among the 383 children with purpura nephritis, the incidence of Yi was higher than that of Han (Yi∶Han = 1.87∶1), the incidence of female children of Yi was higher than that of male children of Yi (Yi female∶Yi male= 1.25∶1), and the incidence of female children of Han was lower than that of male children of Han (Han female: Han male=0.87∶1).70.3% of the renal damages occurred within one month, and the clinical typology was dominated by haematuria and proteinuria, followed by nephrotic syndrome, and the clinical pathology was dominated by haematuria and proteinuria. The clinical typing was dominated by hematuria and proteinuria type, followed by nephrotic syndrome type, and the pathological grading was dominated by grade Ⅱ and Ⅲ, which accounted for 88.4% of the cases. Hematuria and proteinuria type was dominated in pathological grade Ⅱ and Ⅲa, and nephrotic syndrome type was dominated in pathological grade Ⅲb or above, and the difference between the clinical typing and the relationship between pathological grading between the various groups was statistically significant, but the difference in the nephrotic syndrome type in particular was significant (z=2.626，P＜0.001)The higher the quantitative urine protein, the higher the pathological grading. The difference between Han and Yi in the comparison of different pathological grading was statistically significant (z=2.044，P=0.041), and the degree of renal damage appeared to be more severe in Yi children; whereas the difference in the comparison of different genders in pathological grading was not statistically significant (z=0.722，P=0.470) Hormones, immunosuppressants, and ACEI were effective in treatment.Conclusion The incidence of female children of Yi nationality is higher in Liangshan area. The pathological grade is positively correlated with the quantity of urinary protein, and the higher the pathological grade is, and the main clinical classification is nephrotic type. However, there are inconsistencies between pathological grade and urinary protein quantity and clinical classification, so early renal biopsy is very important. Hormone and immunosuppressant therapy is effective, and the prognosis is mostly great