Objective In this study, acellular dermal matrix and artificial derma were used to repair oral soft tissue defects, and the effects of the two repair materials on oral soft tissue healing time, pain and scar formation were compared. Methods Patients with oral soft tissue defect repair due to various reasons in Affiliated Hospital of Xuzhou Medical University from March 2021 to June 2022 were selected as the study objects. 65 patients were randomly divided into observation group (artificial dermal repair group) (33 cases) and control group (acellular dermal matrit repair group) (32 cases) according to the random number table method. The healing rate of the defect area between the two groups was compared. The healing time was recorded in time, the pain, scar formation and wound contraction of the two groups were observed, and relevant statistical analysis was performed.Results All 33 cases of artificial dermis in the observation group survived, and 2 cases of repair materials fell off in the control group 5 days after surgery, with a success rate of 93.75%. The wound healing rates of 2 weeks, 3 weeks and 1 month after surgery in the two groups were analyzed, and the results were all P＜0.05, which was statistically significant, indicating that the healing rates of the observation group at different time points were higher than those in the control group. The pain scores of 1 week, 2 weeks, 3 weeks and 1 month after surgery in the two groups were analyzed, and the results were P＜0.05, which was statistically significant, indicating that the pain level of patients using artificial dermal repair was milder than that of the acellular dermal matrix group. Other postoperative complications were analyzed at 1 day and 3 days after surgery in the two groups, and the results were P＞0.05, which was not statistically significant, indicating that there was no difference in the incidence of other postoperative complications between the two groups. The scarring of the two groups at 3 months after surgery was analyzed, and the result was P＞0.05, which was not statistically significant, indicating that there was no significant difference in scarring between the observation group and the control group. The wound contraction of the two groups at 3 months after surgery was analyzed, and the results showed that the wound shrinkage rate in the observation group was less than that in the control group, and the difference was statistically significant (P＜0.05), indicating that the wound contraction of the two groups was different.Conclusion Compared with acellular dermal matrix, the application of artificial dermis to repair oral soft tissue defect wounds can accelerate the rate of wound healing, shorten the healing time, reduce postoperative pain and discomfort, reduce the rate of repair material loss, to a certain extent prevent wound contraction and inhibit wound scar formation