Objective Based on the theory of qi stagnation and blood stasis, to explore the therapeutic effect of Wuhu oral liquid on acute soft tissue injury. Methods 130 patients with acute soft tissue injury (ASTI) who were hospitalized in our hospital from September 2020 to September 2022 were selected as the study objects. The study objects were divided into the study group (65 cases) and the control group (65 cases) according to the ratio of 1∶1 by the method of random number table. The control group was treated with indomethacin cataplasm, and the study group was treated with Wuhu oral liquid on the basis of the control group. The multi criteria decision-making analysis model of benefit and risk of Wuhu oral liquid in treating ASTI was established. The RevMan5.3 software was used to combine data to obtain the effect values of various benefit indicators and risk indicators and Used Hiview3 software to calculate the benefit value, risk value and benefit risk total value of the study group and the control group, changed the weight of the first level indicators in benefit risk and evaluate the sensitivity of the model.Results After treatment, the patients in the study group were significantly better than those in the control group in tenderness, ecchymosis, swelling, dysfunction, VAS score, pain relief time, swelling relief time, dysfunction relief time, clinical efficacy and adverse reactions;and the levels of TNF- α,IL-6 in the control group were significantly lower than those in the control group. The benefit values of the study group and the control group were 66 and 50 respectively, the risk values were 71 and 93 respectively, and the total benefit risk values were 67 and 57 respectively. The total benefit risk value of the research group was the highest.No matter how the relative weight of benefit risk changed, the model evaluation results remained unchanged, indicating that the model was stable.Conclusion Based on the theory of qi stagnation and blood stasis, the benefits of Wuhu oral liquid in treating ASTI are higher than the risks, and it can reduce the incidence of adverse reactions and provide a basis for rational clinical medication