Objective To analyze the influence of remote ischemic post conditioning (RIPC) on clinical efficacy and cerebral protective effect in patients with cerebral infarction.Methods 110 patients with cerebral infarction admitted to the hospital from January 2022 to December 2022 were selected and divided into 55 cases in conventional group (conventional treatment of cerebral infarction) and 55 cases in RIPC group (RIPC based on conventional group) by the random number table method. The efficacy, and neurological function score, cerebral hemodynamic indicators ［pulsatility index (PI), mean arterial blood flow velocity (Vm)］, serum inflammatory factors ［C-reactive protein (CRP), interleukin-6 (IL-6), transforming growth factor-β (TGF-β)］, cystatin C (CysC) and serum uric acid (UA) before and After 6 months of treatment were compared between the two groups. The recurrence of cerebral ischemia symptoms and occurrence of adverse reactions were recorded. Results After 6 months of treatment, the total effective rate in RIPC group was significantly higher than that in conventional group (P＜0.05) Before treatment, the NHISS score and Barthel score in the two groups revealed no significant differences (P＞0.05)After 6 months of treatment, the NHISS score in the two groups was reduced compared with that before treatment (P＜0.05) while the Barthel score was enhanced (P＜0.05) There were significant differences in the NHISS score and Barthel score between RIPC group and conventional group (P＜0.05). There were no significant differences in Vm and PI between the two groups before treatment (P＞0.05). After 6 months of treatment, the Vm in both groups was increased compared to before treatment (P＜0.05) while the PI was decreased compared with that before treatment (P＜0.05), and there were significant differences in Vm and PI between RIPC group and conventional group (P＜0.05). Before treatment, there were no significant differences in IL-6, CRP and TGF-β between the two groups (P＞0.05). After 6 months of treatment, the IL-6 and CRP were declined compared with those before treatment (P＜0.05)while TGF-β was risen (P＜0.05) The levels of IL-6, CRP and TGF-β showed significant differences between RIPC group and conventional group (P＜0.05).Before treatment, there were no significant differences in CysC and UA between the two groups (P＞0.05), and CysC and UA After 6 months of treatment were lowered compared with those before treatment (P＜0.05), and there were significant differences between RIPC group and conventional group (P＜0.05)There were no statistically significant differences in the recurrence of cerebral ischemia symptoms and adverse reactions between the two groups (P＞0.05)Conclusion RIPC has affirmative clinical effect on patients with cerebral infarction, and it can play a good cerebral protective effect, effectively improve the neurological function and inflammatory response, and regulate the levels of UA and CysC in the body, and it is safe and effective