Objective To investigate the effect and mechanism of tumor related macrophage exoosomes on the growth and metastasis ability of liver cancer cells. Methods The exosomes of M0 and M2 macrophages (M0 exo and M2 exo) were extracted and identified. HepG2 and SMMC-7721 cells were divided into PBS group, M0 exo group and M2 exo group. CCK8 method was used to detect the proliferation ability of hepatoma cells in each group, Transwell method was used to detect the migration and invasion ability of cell migration, flow cytometry was used to detect the cell cycle, SA-β-Gal staining was used to detect the Cellular senescence, and Western blot was used to detect the expression level of P16, P21, HMGA1. Results Both M0 exo and M2 exo conformed to the structure and biological characteristics of exosomes. Compared with PBS group, the proliferation, migration and invasion ability of HepG2 and SMMC-7721 cells in M2 exo group was significantly increased, the G1 of cell cycle was increased, cellular senescence significantly reduced, the expression of aging related proteins P16, P21, and HMGA1 were significantly downregulated (P＜0.05) Conclusion M2 type macrophage exosomes can promote the proliferation, migration, invasion abilities and cell senescence of HepG2 and SMMC-7721