Polycystic ovary syndrome (PCOS) is a common disease leading to infertility for women of childbearing age, damaging the physical and mental health of patients. The abnormal function of hypothalamus-hypophysis-ovary axis and metabolic disorders in PCOS have abundant adverse effects on female reproduction. Assisted reproductive technology (ART) is important means to address the infertility of PCOS, but the high ovarian response of patients increases the risk of ovarian hyperstimulation syndrome (OHSS) and increases the risk and burden of patients subsequently. In order to improve the clinical outcome of ART and decrease the risk of OHSS, it is necessary to optimize the whole process of ART by clinicians. How to optimize the ART strategy for PCOS patients is a hot point in recent years. In this paper, we reviewed the critical points in the whole ART process of PCOS patients, including preconditioning before controlled ovarian stimulation, ovarian stimulation protocol, types and dosages of drugs, and other OHSS prevention strategies, as combined with our team's previous research results and clinical experiences. All above in order to promote the clinical application and research on the individualized ART strategies for PCOS patients