Objective To investigate the clinical value of dual-source CT enhanced multiple-parameter imaging in the diagnosis of pulmonary nodule. Methods A retrospective analysis of 51 patients undergoing dual-source CT from October 2018 to December 2021, including 21 patients diagnosed as benign lung nodules and 30 malignant lung nodules, which were treated as benign and malignant groups, respectively. Dual-source CT-enhanced multi-parametric imaging images were transmitted into the Siemens dual-source CT dedicated Dual-Energy software to record the single-energy CT values at different keV in the nodules by delineating the region of interest. Two-source CT-enhanced multiparameter data were compared, and ROC curves were simultaneously plotted to calculate the threshold for the differential diagnosis of benign and malignant lung nodules for each parameter. Results The NIC, K absolute, iodine base and conventional enhanced CT values in the benign group were significantly higher than those in the malignant group (P <0.01); the CT values at 40keV, 70keV, 100keV, 120keV and 140keV were significantly higher than those in the malignant group (P <0.01).The ROC curve analysis showed that the AUC of NIC was significantly higher than the absolute K and iodine base values (P<0.05), the AUC area of the combined absolute NIC + K value was significantly higher than the diagnosis alone (P <0.05). Conclusion Dual-source enhanced multi-parametric imaging by CT can be used as an effective imaging means for the differential diagnosis of benign and malignant tumors of pulmonary nodule, with the advantages of multiple parameters and quantifiable tumors, and is of great significance for the early diagnosis and treatment guidance of pulmonary nodule