Objective To analyze the risk factors of recurrent foot ulcer (DFU) in diabetes patients based on Logistic regression model and ROC curve. Methods 92 patients with foot ulcer of newly diagnosed type 2 diabetes mellitus (T2DM) admitted to our hospital from September 2018 to September 2019 were retrospectively selected. They were divided into non recurrence group (51 cases) and recurrence group (41 cases) according to the recurrence of foot ulcer within three years. Single factor analysis of foot ulcer recurrence in DFU patients was performed. Multifactor logistic model was used to study the risk factors of foot ulcer recurrence in DFU patients. Spearman test was used to analyze the correlation between each index and foot ulcer recurrence in DFU patients. The diagnostic efficacy of the model was evaluated by the receiver operating characteristic curve (ROC)Results 92 cases of DFU were followed up for 3 years, 41 cases recurred, the recurrence rate was 44.57%. Univariate analysis showed that there was no significant difference (P＞0.05) between the two groups in body mass index (BMI), gender, history of cardiovascular and cerebrovascular diseases, history of hypertension, length of stay, time from onset to visit, ALB, TBIL, Scr, HbA1c, TG, HDL, TC, and LDL. Compared with the non recurrent group, the age, T2DM course, the proportion of diabetes peripheral neuropathy (DPN), the proportion of lower limb peripheral arterial disease (PAD), the proportion of smoking history, and the proportion of wound located in the callus in the recurrent group increased significantly, and the TBIL level decreased significantly (all P＜0.05). Multivariate analysis showed that the risk factors of foot ulcer recurrence in DFU patients were age, long duration of T2DM, DPN, PAD, smoking history, wound location in the callus and decreased serum TBIL level (P＜0.05). Spearman test showed that the recurrence of foot ulcer in DFU patients was positively correlated with age, T2DM course, DPN, PAD, smoking history, and wound location on the callus, while the level of TBIL was significantly decreased and negatively correlated (all P＜0.05) The ROC curve was drawn with unite (seven variable synthesis), age, T2DM course, TBIL, DPN, PAD, smoking, and wound in the callus as test variables. The results showed that the AUC value of unite was 0.834, which was greater than age (0.632), T2DM course (0.619), TBIL (0.645), DPN (0.684), PAD (0.662), smoking (0.640), and wound in the callus (0.677), respectively. Efficacy of the combination of seven indicators in evaluating the recurrence of foot ulcer in DFU patients is significantly better than that of a single indicator (P＜0.05) Conclusion The risk factors of foot ulcer recurrence in DFU patients are aging, long course of T2DM, DPN, PAD, smoking history, wound location in the callus, and low serum TBIL level. If the above conditions are found, we should be highly alert to the risk of foot ulcer recurrence in DFU patients and intervene as soon as possible