Objective To investigate the risk factors of perioperative venous thromboembolism (VTE) in patients with colorectal cancer. Methods This study was a prospective cohort study, including 102 patients who underwent radical resection of colorectal cancer in Nanchong Central Hospital Affiliated to North Sichuan Medical College from June 2021 to April 2022. Exposure indicators were obtained and outcomes were observed. Univariate analysis and multivariate Logistic regression were used to analyze the influencing factors of venous thromboembolism during perioperative period of colorectal cancer.Results Of the 102 patients included, a total of 20 patients experienced VTE during the perioperative period.Univariate analysis showed that there were statistically significant differences between the two groups in terms of age, diabetes mellitus and past history of VTE (P＜0.05), while there were no statistically significant differences in terms of gender, BMI, coronary heart disease, hypertension, anticoagulation therapy 4 weeks before operation, operation mode, operation time, operation position, physical prophylaxis after operation and postoperative laboratory examination indicators.Multivariate Logistic regression analysis showed that age was associated with VTE (P=0.005, OR=1.136).Conclusion The incidence of VTE in perioperative period of colorectal cancer is 19. 6%. For patients over the age of (72.95±9.44) with diabetes mellitus and a history of VTE, perioperative intervention measures should be strengthened to prevent the formation of VTE, and more noteworthy indicators such as operation time and operation position should be considered