Objective To investigate the tumor regression pattern of human epidermal growth factor receptor 2 (HER2) negative breast cancer with axillary lymph node metastasis and analyze its influencing factors. Methods A retrospective analysis was performed on 129 cases of HER2-negative breast cancer with axillary lymph node metastasis diagnosed and treated in the department of breast center of the Affiliated Hospital of Qingdao University from July 2017 to July 2021, and analyzed the influencing factors of tumor regression pattern.χ2 test was used for univariate analysis and binary regression was used for multivariate analysis. Results In HER2-negative breast cancer with axillary lymph node metastasis, 62.02% of breast cancer patients had centralistic regression, 37.98% had non-centralistic regression. Univariate and multivariate analysis showed that there were significant differences in tumor stage and regression mode (P＜0.05)Conclusion The larger the primary tumor, the deeper the invasion, the greater the possibility of non - centripetal regression. In clinical practice, breast-conserving surgery should be carefully selected after neoadjuvant therapy for cT4 primary tumors