Objective To investigate the level of six coagulation indexes in premature infants with intracranial hemorrhage and the value of predicting poor prognosis. Methods 101 premature infants with intracranial hemorrhage who were treated in our hospital from January 2020 to May 2022 were selected as the observation group, and 100 premature infants without intracranial hemorrhage in the same period were selected as the control group. The differences between the two groups in fibrinogen (FIB), D-dimer (D-D), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and international standardized ratio (INR) were compared. Logistic regression model based on six items of blood coagulation was constructed to analyze the value of this model in predicting poor prognosis of children. Results The FIB of the observation group was (2.07±0.32) g/L, which was significantly lower than that of the control group (P＜0.05), while the D-D, PT, APTT, TT and INR were (2.12±0.54) μ g/L, (15.40±0.87) s, (58.98±1.12) s, (22.30±0.87) s and (1.64±0.32), which were significantly higher than that of the control group (P＜0.05).In the observation group, the FIB of moderate and severe bleeding premature infants was (1.85±0.25) g/L, which was significantly lower than that of mild bleeding premature infants (P＜0.05), while D-D, PT, APTT, TT and INR were (2.79±0.56) μg/L, (16.59±0.84) s, (60.17±1.14) s, (23.41±0.89) s and (1.86±0.30), which were significantly higher than those of mild bleeding premature infants (P＜0.05). There was no statistically significant difference in FIB, D-D, PT, APTT, TT and INR of premature infants at different gestational weeks in the observation group (P＞0.05)The FIB of poor prognosis premature infants in the observation group was (1.86±0.23) g/L, which was significantly lower than that of good prognosis premature infants (P＜0.05), while D-D, PT, APTT, TT and INR were (2.67±0.54) μ g/L, (16.22±0.90) s, (60.10±1.12) s, (23.38±0.93) s and (1.75±0.24), which were significantly higher than those of good prognosis premature infants (P＜0.05) The area under the ROC curve of poor prognosis predicted by the logistic regression model with six items of blood coagulation was 0.894 (95%CI 0.811 ～ 0.978), P＜0.05, and the sensitivity and specificity were 75.00% and 96.10%, respectively. Conclusion The FIB of premature infants with intracranial hemorrhage decrease significantly, while D-D, PT, APTT, TT and INR increase, the above six indicators of blood coagulation are related to the degree of hemorrhage and prognosis, the logistic regression model constructed by the six indicators of blood coagulation has certain application value in predicting poor prognosis of children