Objective To investigate the efficacy of enhanced external counterpulsation (EECP) combined with drugs in the treatment of Central retinal artery occlusion（CRAO）. Methods A total of 48 patients (48 eyes) with central retinal artery occlusion diagnosed and treated in our hospital from May 2020 to May 2021 were selected as the research subjects. According to the treatment methods, they were divided into the experimental group of 22 cases (22 eyes), the physical disease control group of 26 cases (26 eyes), and the normal control group of 20 cases (20 eyes). The experimental group received 4 courses of EECP combined with drugs, the physical disease control group was treated with simple drugs and the normal control group received 4 courses of EECP. According to the changes of visual acuity, macular blood flow density, internal carotid artery end-diastolic blood flow velocity (EDV), peak systolic blood flow velocity (PSV) and resistance index (RI) before and after treatment, the curative effects of the two groups were evaluated and compared. Results The total effective rate of the experimental group was 77.3%, while that of the physical disease control group was 53.8%. There was significant difference in the total effective rate between the two groups (P＜0.05). Postoperative VA of the experimental group was significantly improved than that preoperative (P＜0.05), while no significant difference existed between preoperative and postoperative VA of the physical disease control group (P＞0.05). The shorter the duration of disease, the better the clinical efficacy of medication-combined EECP. The clinical efficacy was highly and negatively correlative with the duration of diseases (P＜0.05). The hemodynamic indexes of the internal carotid artery in the normal control group after treatment were significantly increased compared with those before treatment, results the RI after treatment was significantly decreased (P<0.05). After treatment, the indexes of macular blood flow density were significantly increased compared with those before treatment, the difference was statistically significant (P<0.05). The experimental group after treatment were significantly increased in EDV and PSV while significantly decreased in RI (P<0.05). In the physical disease control group, the EDV,PSV and RI were not different comparing before and after treatment(P>0.05). The experimental group after treatment were significantly increased in the blood flow densities of SCP and DCP in the macular area (P<0.05). There was no significant change in the blood flow densities of SCP and DCP in the macular area before and after treatment in the physical disease control group, and the difference was not statistically significant (P>0.05). Conclusion EECP combined with drugs in the treatment of central retinal artery occlusion can significantly improve the clinical efficacy of patients with CRAO, which is worthy of clinical applicatio