Low back pain (LBP) is a common clinical symptom and one of the leading causes of disability and dysfunction. Degenerative lesions account for the majority of the causes of LBP caused by bone and joint, among which intervertebral disc regression is the main trigger, and also involves the lesions of lumbar facet joints, sacroiliac joints, and coccyx. Treatment ranged from conservative to surgical, with pain relief as an outcome for most patients, but no structural repair. In view of the regenerative repair potential of platelet-rich plasma (PRP) therapy and its wide clinical application, this article reviews the research related to PRP and LBP, aiming to explore the efficacy and safety of PRP in the treatment of LBP and related parameter indicators, and accelerate the progress of treatment