Objective To explore the relationship between the degree of inflammatory reaction and the heart and kidney injury in patients with wasp sting. Methods 116 wasp sting patients admitted to our hospital from June 2018 to October 2021 were selected as the case group, and 120 non-wasp sting volunteers who were basically matched in age and sex were selected as the control group. The levels of serum IL-6 and IL-8 were compared between the two groups, and the differences of inflammatory indexes, cardiac function and renal function were analyzed according to whether the patients developed systemic inflammatory response syndrome (SIRS). The correlation between inflammation index and cardiac and renal function index was analyzed.Results The levels of serum IL-6, IL-8 and peripheral blood WBC in the case group were significantly higher than those in the control group, and the PLT was lower than that in the control group, the difference was statistically significant (P<0.05). There was no significant difference in age, height, weight, sex, smoking and alcohol consumption between SIRS group and non-SIRS group (P>0.05). The number of stings in the SIRS group was more than that in the non-SIRS group. The patients in the SIRS group had a longer time to see a doctor than that in the non-SIRS group. The proportion of patients with multiple site stings in the SIRS group was higher than that in the non-SIRS group, and the difference was statistically significant (P<0.05). The levels of serum IL-6, IL-8 and peripheral blood WBC in SIRS group were significantly higher than those in non-SIRS group, and PLT was significantly lower than that in non-SIRS group (P<0.05). The levels of serum CK, CK-MB, AST, LDH, BUN, Scr and UA in patients with SIRS were significantly higher than those in patients without SIRS (P<0.05). The levels of serum IL-6, IL-8 and CK, CK-MB, AST, LDH, Scr and UA in SIRS patients stung by wasps were significantly positively correlated (P<0.05). Conclusion The serum levels of IL-6 and IL-8 in wasp sting patients are significantly higher, and the levels of IL-6 and IL-8 in patients with inflammatory response syndrome are more significantly higher, which is related to the myocardial and renal function damage in patients