Objective To explore the effects of regional medical conjoined MDT model on nutrition intervention and pregnancy outcome of perinatal women. Methods A total of 663 perinatal women who underwent their first prenatal examination in Maternal and Child Health Care Hospital or the department of Obstetrics and Gynecology of China Resources Wisco General Hospital, from January 2019 to April 2019 were divided into the control group and the observation group according to their willingness to participate, including 281 cases in the control group and 382 cases in the observation group. Control group using traditional pregnant women during pregnancy nutrition, weight management pattern, the regional medical couplet body MDT pattern on the observation group of pregnant women prenatal nutrition intervention, compared two groups of patients with pregnancy GWG, BMI before delivery, delivery mode and complications (block, the stages of Postpartum hemorrhage, gestational diabetes, high blood pressure during pregnancy) and Apgar score. Results GWG, BMI, FPG and TC of pregnant women in the observation group before delivery were lower than those in the control group (P＜0.05). The levels of the above indexes in the observation group were (13.49±3.01) kg, (26.75±1.64) kg/m2, (4.82±0.86) mmol/L, (2.82±1.04) mmol/L, Lower than that of control group (15.63±3.46) kg, (27.56±2.37) kg/m2, (7.37±0.69) mmol/L, (6.53±0.78) mmol/L (P＜0.05). Hemoglobin, serum calcium and serum iron in the observation group were higher than those in the control group (P＜0.05). The levels of the above indexes in the observation group were (117.13±9.24) g/L, (1.76±0.23) mmol/L and (7.89±0.24) mmol/L, respectively, higher than that of control group (108.75±12.21) g/L, (1.51±0.46) mmol/L, (7.10±0.76) mmol/L (P＜0.05). The incidence of spontaneous abortion, premature birth and macrosomia in the observation group was lower than that in the control group (P＜0.05). There was no significant difference in the incidence of low birth weight, neonatal malformation and stillbirth between the two groups (P＞0.05). The incidence of gestational diabetes mellitus, gestational hypertension, intrahepatic cholestasis of pregnancy, polyhydramnios before pregnancy and postpartum hemorrhage in the observation group was lower than that in the observation group (P＜0.05). The Apgar score of neonates in the observation group was higher than that in the control group (P＜0.05), the difference was statistically significant. Conclusion Regional medical combination MDT model for perinatal women nutrition intervention is beneficial to reduce the incidence of pregnancy complications.