To analyze the clinical features and prognosis factors of the three-year disease-free survival and overall survival in patients with triple-negative breast cancer.Methods The clinical data of 52 patients with triple-negative breast cancer from January 2005 to January 2019 in Beijing Shijingshan hospital were retrospectively analyzed.Kaplan-Meier method was used for univariate analysis, and those with P≤0.2 were included in Cox regression multivariate analysis to evaluate the relevant prognostic factors affecting triple-negative breast cancer.Results The rate of three-year disease-free survival and overall survival was 76% (40 cases) and 81% (42 cases), respectively.Multivariate analysis showed that age, vascular tumor thrombus，number of primary lesions were independent risk factors for three-year disease-free survival of triple-negative breast cancer.Age, regional lymph node staging, reproductive history were independent risk factors for the overall survival.Conclusion Patients with triple-negative breast cancer had higher rate of recurrence and metastasis in the case of younger age, multiple primary lesions, vascular tumor thrombus.Patients with triple-negative breast cancer had lower rate of overall survival and poorer prognosis in the case of younger age, higher stage of regional lymph node and more times of delivery