To explore the value of PET/MRI imaging and brain function analysis in detecting epileptogenic foci in epilepsy patients. Methods A total of 110 patients with epilepsy who were admitted to our hospital from October 2017 to October 2020 were selected and underwent cranial PET/MRI examination. Deoxyglucose (FDG) was injected before the examination, and then PET (positron emission tomography) was performed after a 30-min rest.), followed by magnetic resonance imaging (MRI) and video electroencephalography (VEEG). Visual analysis, semi-quantitative analysis and brain function analysis were used for PET/MRI image results to determine possible lesions, and postoperative pathological results were used as the gold standard to analyze the diagnostic value of PET/MRI images and brain function analysis in detecting epileptogenic foci in epilepsy patients. Result Taking postoperative pathological results as the "gold standard", the results showed that the pathological results of 110 epilepsy patients were 60.00% (66/110) cerebral cortical dysplasia, 34.55% (38/110) hippocampal sclerosis, and 5.45% (6/110) ganglioglioma. The epileptogenic foci were located in 8.18% (9/110) of the frontal lobe, 9.09% (10/110) of the epileptogenic foci were located in the occipital lobe, and 82.73% (91/110) were located in the temporal lobe. The results of PET/MRI visual analysis and software quantitative analysis of 110 epilepsy patients showed that 69 (62.73%) patients had consistent PET/MRI visual analysis and software quantitative analysis results; 31 (28.18%) patients had PET/MRI imaging results were negative, including 9 cases (8.18%) of suspected lesions. Software analysis showed that the lesions were located in the parietal lobe in 6 cases (5.45%), and in 25 cases (22.73%) in the temporal lobe. PET imaging showed that the epilepsy focus was located in the bilateral temporal lobe in 6 cases (5.45%). The results of brain function analysis shown that 34 cases (30.91%) were positive and 76 cases (69.09%) were negative, including 30 cases (27.27%) with unilateral lesions and 4 cases (3.64%) with bilateral lesions. MIMneuro software analysis showed that PET/MRI had statistical significance in the diagnosis of unilateral lesions, which was consistent with the EEG results. The combined sensitivity of PET/MRI imaging and brain function in detecting epileptogenic foci in epilepsy patients was significantly higher than that of single PET/MRI imaging (t=26.564, P=0.000), and higher than that of single brain function analysis (t=7.875, P=0.004), the difference was statistically significant (P＜0.05). When Z-sorce=-1.81, the sensitivity and specificity of predicting postoperative epilepsy foci recurrence were 81.46% and 77.23%. Conclusion PET/MRI images and brain function analysis can significantly improve the accuracy of epileptogenic foci location in epilepsy patients, provide reliable guidance for surgical resection, and effectively control epileptic seizures, which has high clinical application value