To analyze the clinical characteristics of bloodstream infections caused by Klebsiella pneumoniae and the risk factors for mortality in CRKP bloodstream infections. Methods Data of 136 hospitalized KPBSI patients from July 2020 to December 2021 were collected. The patients were divided into CSKP group and CRKP group, and the differences and similarities between the two groups were compared in department distribution,basic diseases, co-infected sites, susceptibility factors and other aspects. Then the CRKP group was divided into two subgroups, survival group and death group, according to the prognosis after 90 days of bloodstream infection, and the risk factors of death of CRKP were analyzed. Results In terms of hospitalization in ICU, combined pulmonary infection, abdominal infection, severe cardiovascular and cerebrovascular disease, critical burns andtrauma, intubation (gastric tube, urinary catheter, deep vein placement, thoracoabdominal puncture), tracheal intubation/tracheotomy, and surgical procedures, the proportion of patients in the CRKP group was significantly higher than that in the CSKP group (P＜0.05). Conversely, the proportion of patients with combined hepatobiliary tract infection, hematologic/solid malignancies, chemotherapy, and interventional procedures (biliary stenting, abscess puncture and drainage, etc. ) was significantly higher in the CSKP group than in the CRKP group (P＜0.05). The results of multifactorial association analysis suggested that combined multiple organ dysfunction syndrome (OR=46.41,95%CI：4.061~530.340, P=0.002) was an independent risk factor for death in patients with CRKP. Conclusion CRKP is mostly distributed in ICU. Lung and abdominal infection are the common co-infection sites. Patients with severe cardiovascular and cerebrovascular disease, critical burns andtrauma are prone to CRKP infection. All kinds of intubation, endotracheal intubation / tracheotomy are iatrogenic factors of CRKP. Multiple organ dysfunction syndrome was an independent risk factor for death in CRKP.