To explore the effects of polysaccharides from radix kostyniae japonicae on behavior, AQP5 and nasal mucosa tissues in rats with allergic rhinitis based on NF-κB/STAT3 signaling pathway. Methods 40 SPF SD male rats were randomly divided into normal group (N), model group (M), furoic acid mo betamethasone (group F), wind polysaccharide (W) group, each group of 10. Ovalbumin sensitization method was adopted to establish the model of allergic rhinitis. N group is not set up the model. After the success of the modeling, the group F give 1 spray/side furoic acid mo betamethasone nasal spray treatment. The polysaccharide of 600mg/kg was gavaged to group W, and the same volume of normal saline was gavaged to group N and GROUP M at the same time. The general situation of rats was observed and their behavioral scores were scored. The pathological morphology of nasal mucosa tissue was detected by HE staining, and the expression of AQP5 in nasal mucosa tissue was detected by immunohistochemistry. The expression of NF-κB/STAT3 signaling pathway in nasal mucosa was detected by western blotting. Results Before the experiment, all the rats in each group had normal diet and good mental state, and no symptoms such as runny nose, sneezing and nose scratching were observed. After the modeling was completed, the mental state of the rats was significantly deteriorated, eating and activities were significantly reduced, and the coat was disheveled and lustrous, with common nose scratching, frequent sneezing, and a large amount of nasal secretions flowing out of the anterior nasal foramina. After the treatment, the rat feed water are taken gradually returned to normal, good mental state, sneezing, runny nose, scratching nose symptoms before the treatment have obvious relief, no injury, but each rat no obvious change in body weight (P＞0.05). Compared with the N group, a significant rise in M group behavior score (P＜0.05). Compared with M group, F and W groups of behavior score decreased significantly (P＜0.05), and W group reduced significantly than group F (P＜0.05). The nasal mucosa structure of rats in group N was complete, smooth and orderly, and the size of glands was normal. No obvious epithelial necrosis and exfoliation, inflammatory cell infiltration, and obvious vasodilation or congestion were observed. The epithelial structure of the nasal mucosa in group M was disordered and incomplete, with destruction and degeneration of the epithelial cells of the nasal mucosa, ciliary necrosis and even shedding, and obvious glandular hyperplasia, swelling, bleeding and inflammatory cell infiltration. Compared with group M, the pathological status of group F and group W was significantly improved, and the inflammatory cells were significantly reduced. Compared with N group, group M AQP5 protein expression significantly reduced in nasal mucosa (P＜0.05). Compared with group M, F, W group AQP5 protein expression was significantly increased in nasal mucosa (P＜0.05), and W group increased significantly than group F (P＜0.05). Compared with N group, group M NF-kappa B predominate in the nasal mucosa, P-NF-kappa B predominate, STAT3, P-STAT3 protein expression was significantly elevated (P＜0.05). Compared with group M, F, W group NF-kappa B predominate in the nasal mucosa, P-NF-kappa B predominate, STAT3, P-STAT3 protein expression significantly reduced (P＜0.05), and W group than in group F changes significantly (P＜0.05), but no obvious difference was found between group B compared with group W (P＞0.05)，group O were significantly lower than group B (P＜0.05). Conclusion Polysaccharides from P. simokata can effectively improve the behavior and pathological morphology of nasal mucosa in rats with allergic rhinitis, and significantly promote the expression of AQP5, which may be related to the inhibition of NF-κB/STAT3 signaling pathway.