y observing the effect of Kiwi essence on the expression of NPM protein and mRNA in mouse lung adenocarcinoma transplanted tumor, the possible mechanism of Kiwi essence inhibiting tumor growth and metastasis was explored. Methods A mouse transplanted tumor model of lung adenocarcinoma was established. Thirty-two C57BL/6J mice inoculated with Lewis lung adenocarcinoma cells were randomly divided into 4 groups: control group, low-dose (60 mg/kg) Kiwi essence group, medium-dose (120 mg/kg) Kiwi essence group and high-dose (240 mg/kg) Kiwi essence group, with 8 mice in each group. From the 4th day after inoculation, all mice were given corresponding drug intervention. On the 24th day, all mice were sacrificed, the transplanted tumors were separated, the volume of transplanted tumors and the mass of transplanted tumors were measured, the tumor inhibition rate was calculated, the number of tumor metastatic nodules in mice was counted, the tumor lung metastasis inhibition rate was calculated, the expression level of NPM protein in subcutaneous transplanted tumor tissues of mice was detected by immunohistochemistry and Western blot, and the NPM mRNA level in transplanted tumor tissues was determined by fluorescence real-time quantitative PCR. Results Compared with the control group, the mass and volume of subcutaneous transplanted tumor tumors in mice in the Kiwi essence group were significantly reduced, the number of metastatic nodules in mice was also significantly reduced, the expression levels of NPM protein and mRNA in subcutaneous transplanted tumor tissues of mice were decreased and the concentration of Kiwi essence was significantly different. The above indicators were significantly different, and the daily difference was statistically significant. Conclusion Kiwi essence may inhibit the growth and metastasis of lung adenocarcinoma transplanted tumor in mice by down-regulating the expression of NPM gene.