To analyze the application value of goserelin acetate combined with laparoscopic surgery in the treatment of endometriosis (EMT) of patients. Methods The clinical data of 110 EMT patients admitted to this hospital from January 2016 to December2020 were collected. According to different treatment methods, they were divided into simple group (n=54 cases, laparoscopic surgery) and combined group (n=56 cases, goserelin acetate combined with laparoscopic surgery). The clinical efficacy, ovarian function, ovulation, menstrual recovery time, pregnancy rate, patency rate of fallopian tube, recurrence rate and adverse reactions were compared between the two groups. Results The total effective rate after treatment in the single group was 83.33%, and that in the combined group was 96.43%, which was significantly higher than that in the control group (P＜0.05). After treatment, the levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) in the two groups were significantly lower than those before treatment. The levels of the above factors decreased more significantly in the combined group (P＜0.05). The recovery time of ovulation in the combined group were shorter than those in the simple group, and the menstrual recovery time was longer than that of the simple group(P＜0.05). The pregnancy rate and patency rate of fallopian tube of the combined group were significantly higher than those of the simple group, and the recurrence rate and the total incidence of adverse reactions were lower than those of the simple group (P＜0.05). Conclusion Goserelin acetate combined with laparoscopic surgery has a definite effect in the treatment of EMT patients, which can effectively improve the patient's ovarian function, increase pregnancy rate, and reduce recurrence rate.