To observe the effect of acupuncture therapy of Midnight Noon Ebb Flow on chronic obstructive pulmonary disease with lung kidney qi deficiency syndrome in stable stage. Methods 60 patients were randomly divided into observation group and controlled group, with 30 cases in each group. Patients in both groups were treated with acupuncture on the basis of routine western medicine. The observation group was treated with acupuncture therapy of Midnight-Noon Ebb-Flow, according to this method to select acupoints and carried out acupuncture treatment at Mao period, while the controlled group was treated with routine dialectical acupoint selection at other times. After treatment, the clinical efficacy, TCM symptom integral, FEV1，FEV1%，6MWT, modified MRC dyspnea scale (mMRC) and BODE index were compared between the two groups. Results The total effective rate of the observation group was 93.3%, which was significantly higher than that of the controlled group (70.0%)(P＜0.05). Before treatment, there were no significant differences in TCM symptom integral, FEV1, FEV1%, mMRC and BODE index between the two groups (P＞0.05). After treatment, the TCM symptom integral, FEV1, FEV1%, mMRC and BODE index of the two groups were decreased, and the observation group was lower than the control group (P＜0.05). The FEV1, FEV1% and 6MWT in both groups were increased, and which of the observation group was higher than that of the control group (P＜0.05). There were no serious adverse reactions in the two groups during treatment. Conclusion Acupuncture therapy of Midnight-Noon Ebb-Flow is more effective in the treatment of chronic obstructive pulmonary disease of lung-kidney qi deficiency syndrome in stable stage, which can improve the clinical efficacy and reduce the symptoms of patients, and can be popularized in clinical application.